FORMULASI DAN UJI AKTIVITAS ANTIBAKTERI SEDIAAN SABUN CAIR EKSTRAK SABUT KELAPA (Cocos nucifera L. ) DENGAN VARIASI KONSENTRASI CARBOPOL 940 TERHADAP BAKTERI Staphylococcus aureus ATCC 25923
DOI:
https://doi.org/10.26418/edunaturalia.v4i1.61425Abstract
Shower gel is one of the preparations that can be used to protect the skin from Staphylococcus aureus bacterial infection. Plants that have antibacterial activity are coconut husk, the compounds contained are tannins, flavonoids, and polyphenols. Tannins have the activity of inhibiting the growth of Staphylococcus aureus bacteria. This study aims to determine the influence of Carbopol 940 variations on liquid soap preparations. Liquid soap preparations have antibacterial activity, find out which formulas have the best physical quality. Coconut husk extract was obtained by maceration method using 70% ethanol solvent. The concentration of coconut husk extract in the formula is 1.6% with a variation in the concentration of Carbopol 940 which is 0.5%, 1%, 1.5%. Physical quality examination includes organoleptic test, homogeneity test, pH test, viscosity, foam stability test, and free alkali test. Testing the antibacterial activity of liquid soap preparations using the method of diffusion of wells, the data obtained by analysis using the SPSS program. Variations in carbopol concentration 940 affect the physical quality of liquid soap preparations, the increasing concentration of carbopol affects viscosity, foam stability, and free alkali. All formulas have antibacterial activity of 21.23 (F4); 20.22 (F5); 19.37 (F6). The formula with the best physical quality and inhibitory power is formula 4 with a carbopol concentration of 940 of 0.5%.
References
Adjeng, A. N. T., Hairah, S., Herman, S., Ruslin, R., Fitrawan, L. O. M., Sartinah, A., Ali, N. F. M., & Sabarudin, S. (2019). Skrining Fitokimia dan Evaluasi Sediaan Sabun Cair Ekstrak Etanol 96% Kulit Buah Salak Pondoh (Salacca zalacca (Gaertn.) Voss.) Sebagai Antioksidan
Agusta, W. (2016). Optimasi Formula Sabun Cair Antibakteri Ekstrak Etanol Daun Sirih Merah (piper Crocatum Ruiz & Pav) Dengan Variasi Konsentrasi Virgin Coconut Oil VCO) dan Kalium Hidroksida. Naskah Publikasi Fakultas Kedokteran Universitas Tanjungpura, 3-5
Dalimunthe, Aminah, Marline Nainggolan. “Pengujian ekstrak etanol sabut kelapa (Cocos nucifera Linn) terhadap bakteri Escherichia coli dan Shigella dysenteriaeâ€. Medan: FMIPA Universitas Sumatera Utara, 2006. Diakses pada tanggal 25 november 2011
Departemen Kesehatan Republik Indonesia, 1995, Farmakope Indonesia, Edisi IV, 606, Departemen Kesehatan Republik Indonesia, Jakarta
Depkes RI. 2008. Pengelolaan Pasca Panen Tanaman Obat. Balai Penelitian Pengembangan Tanaman Obat dan Obat Tradisional. Jakarta: Departemen Kesehatan Republik Indonesia
Dewi, A.K., 2013. isolasi , identifikasi dan uji sensitivitas staphylococcus aureus terhadap amoxicillin dari sampel susu kambing peranakan ettawa ( PE ) penderita mastitis di wilayah Girimulyo, Kulonprogo, Yogyakarta. Sain Veteriner, 31(2), pp.138–150.
Fitriyanti et al., 2019. uji aktivitas antibakteri ekstrak metanol daun jeruk purut (citrus hystrix (d.c)) terhadap bakteri propionibacterium acnes. Jurnal Ilmiah Ibnu Sina, Vol :5(1)
Harborne, J.B., (1987), Metode Fitokimia, Edisi ke dua, ITB, Bandung.
Ismail I, Haeria, dan Ahmad F.F. 2016. Potensi pemanfaatan ekstrak sabut kelapa (cocos nucifera linn.) Sebagai antiseptik dalam bentuk sediaan gel. JF FIK UINAM Vol: 4(4)
Jawetz E, Melnick , J L, EA, 2012. Medical Microbiology. 26th. Ed. Elferia Nr. Penerjemah; Jakarta: Penerbit Buku Kedokteran EGC.
Jiwintarum, Y., Sri Gede, L., & Rahmawati, A. 2018. Perbedaan hasil uji koagulase menggunakan plasma sitrat manusia 3, 8%, plasma sitrat domba 3, 8%, dan plasma sitrat kelinci 3, 8% pada bakteri Staphylococcus aureus. Jurnal kesehatan prima, 9(2), 1559-1569
Kementerian Kesehatan Republik Indonesia. 2017. Farmakope Herbal Indonesia. Edisi II. Kementerian Kesehatan Republik Indonesia. Jakarta
Kurniawati, E. 2017. Daya antibakteri ekstrak etanol tunas bambu apus terhadap
bakteri Escherichia coli dan Staphylococcus aureus secara in vitro. Jurnal Wiyata: Penelitian Sains dan Kesehatan, 2(2), 193-199
Lisan, F. R dan S. Palupi. 2015. Penentuan jenis tanin secara kualitatif dan penetapan kadar tanin dari sabut kelapa (Cocos nucifera L.) secara permanganometri. Jurnal Ilmiah Mahasiswa Universitas Surabaya. Vol.4(1) : 1-16.
Lutpiatina, 2017. Cemaran Staphylococcus aureus dan Pseudomonas aerogenosa Pada Stetoskop dirumah sakit. Jurnal Teknologi Laboratorium, vol. 6(2).
Masykura, A., dan Puspasari, H. 2022. Aktivitas Antibakteri Nanopartikel Perak (NPP) Hasil Biosintesis Menggunakan Ekstrak Keladi Sarawak Alocasia macrorrhizos Terhadap Staphylococcus aureus Dan Escherichia coli. BIOMA: Jurnal Biologi Makassar, 7(1): 76-85.
Maulida. H. 2018 UJI Efek Antibakteri Ekstrak Etanol Daun Kemangi (Ocimum tenuiflorum L.) Terhadap Pertumbuhan Bakteri Staphylococcus aureus.
Paramita, D.N., Wahyudi, M.T. 2011. Uji Efek Antibakteri Infusum Teh Hijau (Camelia sinensis) terhadap Bakteri Staphylococcus aureus in vitro. Jurnal Medika Planta, 1(3): 67-74
Septyaningsih, D. 2010. Isolasi Dan Identifikasi Komponen Utama Ekstrak Biji Buah Merah (Pandanus conoideus Lamk.). Skripsi. Fakultas Matematika Dan Ilmu Pengetahuan Alam. Universitas Sebelas Maret. Surakarta
Sinko, P. J. 2011. Martin Farmasi Fisika Dan Ilmu Farmasetika Edisi V. UI Press, Jakarta
Widiyastuti, Y. 2020. Pengembangan Parameter Standar Simplisia Untuk Menjamin Mutu Dan Keamanan Obat Tradisional: Orasi Pengukuhan Profesor Riset Bidang Tanaman Obat dan Obat Tradisional.
Wulandari A. 2018. Aktivitas Antibakteri Ekstrak Etanol Sabut Kelapa (Cocos nucifera Linn) Pada Berbagai Tingkat Ketuaan. Jurnal Kovalen Vol.4(3).
Yuniarsih, Nia, Fauzi Akbar, Icha Lenterani, and Farhamzah. 2020. “Formulasi Dan Evaluasi Sifat Fisik Facial Wash Gel Ekstrak Kulit Buah Naga Merah (Hylocereus polyrhizus) Dengan Gelling Agent Carbopol.†Pharma Xplore : Jurnal Ilmiah 5(2):57–67. https://doi.org//10.36805/farmasi.v5i2.1194.
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