Prevalensi Early Neurological Deterioration berdasarkan Komponen Leukosit pada Pasien Strok Iskemik di RSUD dr. Abdul Aziz Singkawang Tahun 2014
DOI:
https://doi.org/10.26418/jurkeswa.v1i3.64096Keywords:
Jumlah leukosit, Early Neurological Deterioration, Strok IskemikAbstract
Latar Belakang. Strok adalah penyakit pada otak berupa gangguan fungsi saraf lokal dan atau global, munculnya mendadak, progresif, dan cepat. Strok dapat menyebabkan turunnya kualitas hidup dikarenakan kerusakan sel otak sehingga terjadi penurunan fungsi neurologis dini atau disebut juga early neurological deterioration (END). Belum didapatkannya data mengenai jumlah kejadian END berdasarkan komponen leukosit pada pasien strok iskemik. Metode. Penelitian ini merupakan penelitian deskriptif dengan pendekatan potong lintang. Pengumpulan data dilakukan di bagian Rekam Medis RSUD dr. Abdul Azis Singkawang pada bulan Juli-September 2015. Data dikumpulkan dari rekam medis semua pasien strok iskemik yang dirawat di RSUD dr. Abdul Azis Singkawang tahun 2014, yang diambil secara consecutive sampling. Data univariat disajikan untuk melihat distribusi dari variabel penelitian. Hasil. Tercatat 92 kasus strok iskemik pada tahun 2014 dan hanya 41 kasus yang memenuhi kriteria penelitian. Sebanyak 41 pasien yang strok iskemik, 22 pasien (53,7%) mengalami leukositosis, 21 pasien (51,2%) mengalami neutrofilia, dan 4 orang (9,8%) mengalami limfositosis. Sebanyak 11 dari 16 pasien leukositosis (68,75%) mengalami END, 12 dari 18 pasien neutrofilia (66,67%) mengalami END dan 1 dari 2 pasien limfositosis (50%) mengalami END. Kesimpulan. Angka prevalensi kejadian END pada pasien strok iskemik yang mengalami leukositosis sebanyak 11 pasien (68,75%), 12 pasien (66,67%) pada neutrofilia dan 1 pasien (50%) pada limfositosis.References
Feigin VL, Lawes CMM, Bennett DA, Barker-Collo SL, Parag V. Worldwide stroke incidence and early case fatality reported in 56 population-based studies: a systematic review.The Lancet Neurology.2009; 8(4): 355-369.
Feigin VL. Pendaluhuan. Stroke Panduan Bergambar Tentang Pencegahan dan Pemulihan Stroke. Jakarta: Penerbit PT Bhuana Ilmu Populer; 2006.
Sacco RL, Kasner SE, Broderick J P, Caplan LR, Connors JJ, Culebras A, et al. ; on behalf of the American Heart Association Stroke Council, Council on Cardiovascular Surgery and Anesthesia, Council on Cardiovascular Radiology and Intervention, Council on Cardiovascular and Stroke Nursing, Council on Epidemiology and Prevention, Council on Peripheral Vascular Disease, and Council on Nutrition, Physical Activity and Metabolism. An Updated definition of stroke for 21st century : statement for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2013;44:2064-2089
O’Donnell M, Yusuf S, Tackling the global burden of stroke : the need for large-scale international studies. LancetNeurol. 2009;8(4):306-7
Feigin VL, Forouzanfar MH, Krisnamurthi R, Mensah GA, Connor M, Bennet Moran AE, et al., on behalf of the Global Burden of Diseases, Injuries, and Risk Factors Study 2010 (GBD 2010) and the GBD Stroke Experts Group. Global and regional burden of stroke during 1990-2010: findings from the Global Burden of Disease Study 2010. The Lancet. 2014:383 245-255
Kusuma Y, Venketasubramanian N, Kiemas LS, Misbach J. Burden of stroke in Indonesia. Int J Stroke. 2009 Oct;4(5): 378-80.
Wei Sun, Amanda Peacock, Jane Becker, Barbara Phillips-Bute, Daniel T. Laskowitz and Michael L. James. Correlation of Leukocytosis with early neurological deterioration following supratentorial intracerebral hemorrhage. J Clin Neurosci. Aug 2012; 19(8): 1096-1100.
Hartl R, Medary MB, Ruge M, Arfors KE, Ghajar J. Early white blood cell dynamics after traumatic brain injury: effect on the cerebral microcirculation. J Celeb Blood Flow Metab. 1997;17:1210-1220
Liesz A, Ruger H, Purrucker J, Zorn M, Dalpke A, Mohlenbruch M, Englert S, Nawroth PP, Veltkamp R. Stress mediators and immune dusfunction in patients with acute cerebrovascular disease. PloS One. Sep 2013;8(9):e74836.
Sri Wahyuni Hatta, Muhammad Ilyas, Bachtiar Murtala, Frans Liyadi. Profil Hitung Leukosit Pada Fase Akut Strok Hemoragik dan Strok Iskemik Dihubungkan Volume Lesi Pada Pemeriksaan CT Scan Kepala. 2010.
Pozzilli C, Lenzi GL, Argentino C, et al. Imaging of leukocytic infiltration in human cerebral infarcts. Stroke. 1985;16:251-255
Wu H, Chong Y, Wang D, Zhao R, Qi J. Correlation of macrophage inflammatory protein-2-expression and brain edema in rats after intracerebral hemorrhage. Int J Chin Exp Pathol. 2009;2:83-90.
Young DK, Dongbeom S,Eun HK, Ki JL, Hye SL, Chung MN, et al. Long-term mortality according to the characteristics of early neurological deterioration in ischemic stroke patients. Yonsei Med J, 2014. 55(3): 669-75.
Alawneh JA,Moustafa RR, Baron JC. Hemodynamic factors and perfusion abnormalities in early neurological deterioration. Stroke. 2009;40: e443-50. 15. Wang Q, Chen C, Chen XY, Han JH, Soo Y, Leung TW, Mok V, Wong KS. Low-Molecular-Weight Heparin and Early Neurologic Deterioration in Acute Stroke Caused by Large Artery Occlusive Disease. Arch Neural. Nov 2012; 69(11): 1454-9. 16. Jørgensen HS, Nakayama H, Raaschou HO, Olsen TS. Intracerebral hemorrhage versus infarction: Stroke severity, risk factors and prognosis. Ann Neurol. 1995; 38: 45–50
Huwae, LBS. Kaelan, C. Muis, A. Aliah , A. Arif, M. Ganda, IJ. Hubungan Kadar Neutrofil dengan Luaran Klinis Penderita Stroke Iskemik Akut. Jurnal Pasca Sarjana Universitas Hasanudin. 2010.
Kammersgaard, LP. Survival after stroke; Risk factors and determinants in the Copenhagen Stroke Study. Danish Medical Bulletin. 2010.
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