Gambaran Kejadian Penurunan Fungsi Ginjal Yang Ditandai Klirens Kreatinin Pada Pasien Gagal Jantung Kronis di RSUD Dr Soedarso Pontianak
DOI:
https://doi.org/10.26418/jurkeswa.v11i1.91186Keywords:
Sindrom Kardiorenalis, Gagal Jantung Kronis, Penurunan Fungsi Ginjal, Klirens Kreatinin, Gagal Ginjal KronisAbstract
Latar Belakang: Disfungsi jantung dan ginjal seringkali terjadi bersamaan dan saling memengaruhi, suatu kondisi yang dikenal sebagai Sindrom Kardiorenal (SKR). Sekitar 40-60% pasien di Amerika Serikat yang dirawat di rumah sakit dengan Gagal Jantung Kronis (GJK) mengembangkan Gagal Ginjal Kronis (GGK). Pasien GJK yang menunjukkan penurunan fungsi ginjal terkait dengan tingkat mortalitas yang lebih tinggi. Metode: Desain penelitian ini adalah deskriptif observational pada pasien GJK yang dilakukan di Rumah Sakit Umum Daerah (RSUD) dr. Soedarso Pontianak dari bulan Mei 2023 hingga Juni 2024. Teknik pengambilan sampel pada penelitian ini menggunakan total sampling dengan jumlah sampel sebanyak 42 sampel dari tahun 2022 "“ 2023. Penelitian ini menggunakan data sekunder sebagai jenis data dan rekam medik yang terdapat nama pasien, usia, jenis kelamin, tanggal tindakan, berat badan, tinggi badan, diagnosis klinis, hasil ukur alat diagnosis, hasil diagnosis, serta serum kreatinin. Data berupa berat badan dan tinggi badan diolah menggunakan rumus indeks massa tubuh untuk menentukan gambaran fungsi ginjal berdasarkan status gizi. Data berupa usia, jenis kelamin, beratn badan, dan serum kreatinin diolah menggunakan rumus Cockroft-Gault untuk mengetahui gambaran fungsi ginjal. Hasil: Penelitian ini menunjukkan bahwa dari 42 subjek penelitian yang terdiagnosis GJK, ditemukan sebesar 61,9% mengalami penurunan fungsi ginjal, dan dari 26 subjek penelitian yang mengalami penurunan fungsi ginjal, ditemukan sebesar 61,5% menurun ringan dan 38,5% menurun sedang. Kesimpulan: Ditemukan adanya risiko penurunan fungsi ginjal pada pasien GJK dengan risiko paling besar pada kejadian fungsi ginjal menurun ringan.
References
McCallum W, Testani JM. Updates in Cardiorenal Syndrome. Med Clin North Am. 2023 Jul; 107(4): 763-80.
Patel KP, Katsurada K, Zheng H. Cardiorenal Syndrome: The Role of Neural Connections Between the Heart and the Kidneys. Circ Res. 2022 May 13; 130(10): 1601-17.
Kumar U, Wettersten N, Garimella PS. Cardiorenal Syndrome: Pathophysiology. Cardiol Clin. 2019 Aug; 37(3): 251-65.
Prastaro M, Nardi E, Paolillo S, Santoro C, Parlati ALM, Gargiulo P, et al. Cardiorenal syndrome: Pathophysiology as a key to the therapeutic approach in an under-diagnosed disease. J Clin Ultrasound. 2022; 50(8): 1110-24.
Gembillo G, Visconti L, Giusti MA, Siligato R, Gallo A, Santoro D, et al. Cardiorenal Syndrome: New Pathways and Novel Biomarkers. Biomolecules. 2021 Oct 26; 11(11): 1581.
Kementerian Kesehatan RI. Riset Kesehatan Dasar 2018. Jakarta: Badan Penelitian dan Pengembangan Kesehatan; 2018.
Loscalzo J, Fauci AS, Kasper DL, Hauser S, Longo DL, Jameson JL. Harrison's principles of Internal Medicine. 21st ed New York: Mc Graw Hill; 2022.
Patel RB, Fonarow GC, Greene SJ, Zhang S, Alhanti B, DeVore AD, et al Kidney Function and Outcomes in Patients Hospitalized With Heart Failure. J Am Coll Cardiol. 2021 Jul 27; 78(4): 330-43.
Lv JC, Zhang LX. Prevalence and Disease Burden of Chronic Kidney Disease. Adv Exp Med Biol. 2019; 1165: 3-15.
Kovesdy CP. Epidemiology of chronic kidney disease: an update 2022. Kidney Int Suppl. 2022 Apr; 12(1): 7-11.
Welly W, Rahmi H. Self Efficacy Dengan Kualitas Hidup Pasien Gagal Ginjal Kronik Yang Menjalani Hemodialisa. Jurnal Keperawatan Abdurrab. 2021; 5(1): 38-44.
Carmena R, Ascaso JF, Redon J. Chronic kidney disease as a cardiovascular risk factor. J Hypertens. 2020 Nov; 38(11): 2110-21.
The Cardiorenal Syndrome in Heart Failure. Heart Fail Clin. 2020 Jan; 16(1): 81-97.
Pullakanam ST, Krishna B, Madhuri N, Dhas PK, Ramakrishna N. Evaluation of kidney disease using e-GFR compared to measured creatinine clearance. Bioinformation. 2024 Mar 31; 20(3): 229-33.
Steinke T, Moritz S, Beck S, Gnewuch C, Kees MG. Estimation of creatinine clearence using plasma creatinine or cystatin C: a secondary analysis of two pharmacokinetic studies in surgical ICU patients. BMC Anesthesiology; 2015.
American Family Physician. Chronic Kidney Disease: Evaluation and Treatment Guidelines from the VA/DoD. Am Fam Physician. 2020; 102(6): 378-9
Rangaswami J, Bhalla V, Blair JEA, Chang TI, Costa S, Lentine KL, et al. Cardiorenal Syndrome: Classification, Pathophysiology, Diagnosis, and Treatment Strategies: A Scientific Statement From the American Heart Association. Circulation. 2019 Apr 16;139(16): 840-78.
Patel RB, Fonarow GC, Greene SJ, Zhang S, Alhanti B, DeVore AD, et al. Kidney Function and Outcomes in Patients Hospitalized With Heart Failure. J Am Coll Cardiol. 2021 Jul 27; 78(4): 330-43.
McCallum W, Sarnak MJ. Cardiorenal Syndrome in the Hospital. Clin J Am Soc Nephrol. 2023 Jul 1; 18(7): 933-45.
GBD-NHLBI-JACC Global Burden of Cardiovascular Diseases Writing Group. Global Burden of Cardiovascular Diseases and Risk Factors, 1990-2019: Update From the GBD 2019 Study. J Am Coll Cardiol. 2020 Dec 22; 76(25): 2982-3021.
Triposkiadis F, Xanthopoulos A, Parissis J, Butler J, Farmakis D. Pathogenesis of chronic heart failure: cardiovascular aging, risk factors, comorbidities, and disease modifiers. Heart Fail Rev. 2022 Jan; 27(1): 337-44.
Sherly U, Sjaaf F, Puspita D. Profil Pasien Gagal Jantung Pada Usia Lanjut di RSUP Dr. M. Djamil Padang Tahun 2018-2020. Scientific journal. 2022; 1(3): 165-73.
Lakicevic N, Paoli A, Roklicer R, Trivic T, Korovljev D, Ostojic SM, et al. Effects of Rapid Weight Loss on Kidney Function in Combat Sport Athletes. Medicina (Kaunas). 2021 May 31; 57(6): 551.
Zheng CM, Lee YH, Chiu IJ, Chiu YJ, Sung LC, Hsu YH, Chiu HW. Nicotine Causes Nephrotoxicity through the Induction of NLRP6 Inflammasome and Alpha7 Nicotinic Acetylcholine Receptor. Toxics. 2020 Oct 26; 8(4): 92.
Kjaergaard AD, Teumer A, Witte DR, Stanzick KJ, Winkler TW, Burgess S, Ellervik C. Obesity and Kidney Function: A Two-Sample Mendelian Randomization Study. Clin Chem. 2022 Mar 4; 68(3): 461-72.
Johnson RJ, Sanchez-Lozada LG, Newman LS, Lanaspa MA, Diaz HF, Lemery J, et al. Climate Change and the Kidney. Ann Nutr Metab. 2019; 74 Suppl 3: 38–44.
Kida K, Miyajima I, Suzuki N, Greenberg BH, Akashi YJ. Nutritional management of heart failure. J Cardiol. 2023 Mar; 81(3): 283-91.
Park S, Lee S, Kim Y, Lee Y, Kang MW, Kim K, et al. Causal linkage between adult height and kidney function: An integrated population-scale observational analysis and Mendelian randomization study. PLoS One. 2021 Jul 29; 16(7): e0254649.
Ardiansyah D, Farizal J, Irnameria D. Gambaran Kadar Kreatinin Pada Pasien Penyakit Jantung Koroner Di Ruang ICCU RSUD dr. M. Yusuf Provinsi Bengkulu. Bengkulu: Journal of Nursing and Public Health. 2018; 2(6): 14-8.
Komanek T, Rabis M, Omer S, Peters J, Frey UH. Quantification of left ventricular ejection fraction and cardiac output using a novel semi-automated echocardiographic method: a prospective observational study in coronary artery bypass patients. BMC Anesthesiol. 2023 Feb 28;2 3(1):65.
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