Narrative literature review: Effect of Branched-chain Amino Acids (BCAAs) on muscle hypertrophy and athletic performance
DOI:
https://doi.org/10.26418/tajor.v2i2.78568Keywords:
Sports Nutrition, Branched-chain Amino Acids, Athletic Performance, Muscle Recovery, Dietary SupplementationAbstract
Background and Study Aim. Branched-chain amino acids (BCAAs) have received considerable attention in sports science due to their potential benefits in improving athletic performance and promoting muscle recovery. BCAAs including leucine, isoleucine, and valine, are essential amino acids that are important for muscle protein physiology. To date, studies have shown positive effects of BCAAs supplementation on muscle recovery, muscle soreness, and cognitive function. Hence, with the growing popularity of using dietary supplements for optimal athletic performance, this narrative literature review aims to investigate the role and potential of BCAAs supplementation to influence muscle function and improve physical performance, while highlighting the potential benefits and side effects associated with their supplementation.
Material and Methods. The current review was conducted according to PRISMA (Preferred reporting items for systematic review and meta-analysis) guidelines. Electronic databases including Web of Science (all databases), PubMed, Scopus, Google Scholar, Science Direct, were explored on June 11, 2022.
Results. Based on recent evidence, BCAAs have been shown to reduce muscle damage, improve muscle recovery and repair, increase muscle protein synthesis, and maintain muscle mass during periods of energy restriction, however may also have some potential side effects such as liver damage, kidney dysfunction and negative effects on glucose metabolism.
Conclusion. In conclusion, studies investigating the potential benefits of BCAAs obtained from supplementation and diet to improve athletic performance are promising due to their demonstrated effects in increasing muscle protein synthesis, reducing muscle soreness, and improving cognitive function under stress. Nevertheless, excessive supplementation should be avoided due to the potential risk of toxicity and side effects.
References
Areces, F., Salinero, J. J., Abian-Vicen, J., González-Millán, C., Gallo-Salazar, C., Ruiz-Vicente, D., Lara, B., & Del Coso, J. (2014). A 7-day oral supplementation with branched-chain amino acids was ineffective to prevent muscle damage during a marathon. Amino Acids, 46(5), 1169–1176. https://doi.org/10.1007/s00726-014-1677-3
Bailey, S. J., Winyard, P., Vanhatalo, A., Blackwell, J. R., DiMenna, F. J., Wilkerson, D. P., Tarr, J., Benjamin, N., & Jones, A. M. (2009). Dietary nitrate supplementation reduces the O2 cost of low-intensity exercise and enhances tolerance to high-intensity exercise in humans. Journal of Applied Physiology, 107(4), 1144–1155. https://doi.org/10.1152/japplphysiol.00722.2009
Bassit, R. A., Sawada, L. A., Bacurau, R. F. P., Navarro, F., & Costa Rosa, L. F. B. P. (2000). The effect of BCAA supplementation upon the immune response of triathletes. Medicine and Science in Sports and Exercise. https://doi.org/10.1097/00005768-200007000-00005
Blanchet, S., & Ranjan, N. (2022). Translation Phases in Eukaryotes. In Methods in Molecular Biology. https://doi.org/10.1007/978-1-0716-2501-9_13
Blomstrand, E., Ek, S., & Newsholme, E. A. (1996). Influence of ingesting a solution of branched-chain amino acids on plasma and muscle concentrations of amino acids during prolonged submaximal exercise. Nutrition, 12(7–8), 485–490. https://doi.org/10.1016/s0899-9007(96)91723-2
Blomstrand, E., Eliasson, J., Karlssonr, H. K. R., & Köhnke, R. (2006). Branched-chain amino acids activate key enzymes in protein synthesis after physical exercise. Journal of Nutrition, 136(1). https://doi.org/10.1093/jn/136.1.269s
D. Tambalis, K., & Arnaoutis, G. (2022). The Importance of Branched-chain Amino Acids and Nitrate in Sports Performance and Health. Journal of Physical Activity Research, 7(1), 37–46. https://doi.org/10.12691/jpar-7-1-6
De Palo, E. F., Gatti, R., Cappellin, E., Schiraldi, C., De Palo, C. B., & Spinella, P. (2001). Plasma lactate, GH and GH-binding protein levels in exercise following BCAA supplementation in athletes. Amino Acids. https://doi.org/10.1007/s007260170061
Dyachok, J., Earnest, S., Iturraran, E. N., Cobb, M. H., & Ross, E. M. (2016). Amino acids regulate mTORC1 by an obligate two-step mechanism. Journal of Biological Chemistry, 291(43), 22414–22426. https://doi.org/10.1074/jbc.M116.732511
Farra, S. D. (2023). Acute consumption of a branched chain amino acid and vitamin B-6 containing sports drink does not improve multiple sprint exercise performance, but increases post-exercise blood glucose. Frontiers in Nutrition, 10(34), 1266422. https://doi.org/10.3389/fnut.2023.1266422
Fernstrom, J. D. (2005). Branched-chain amino acids and brain function. Journal of Nutrition, 135(6), 1539S1546S. https://doi.org/10.1093/jn/135.6.1539s
Froiland, K., Koszewski, W., Hingst, J., & Kopecky, L. (2004). Nutritional Supplement Use among College Athletes and Their Sources of Information. International Journal of Sport Nutrition and Exercise Metabolism, 14, 104–120. https://doi.org/10.1123/ijsnem.14.1.104
Gervasi, M., Sisti, D., Amatori, S., Donati Zeppa, S., Annibalini, G., Piccoli, G., Vallorani, L., Benelli, P., Rocchi, M. B. L., Barbieri, E., Calavalle, A. R., Agostini, D., Fimognari, C., Stocchi, V., & Sestili, P. (2020). Effects of a commercially available branched-chain amino acid-alanine-carbohydrate-based sports supplement on perceived exertion and performance in high intensity endurance cycling tests. Journal of the International Society of Sports Nutrition, 17(1). https://doi.org/10.1186/s12970-020-0337-0
Hao, F., Kondo, K., Itoh, T., Ikari, S., Nada, S., Okada, M., & Noda, T. (2018). Rheb localized on the Golgi membrane activates lysosomelocalized mTORC1 at the Golgi-lysosome contact site. Journal of Cell Science, 131(3). https://doi.org/10.1242/jcs.208017
Jewell, J. L., Kim, Y. C., Russell, R. C., Yu, F. X., Park, H. W., Plouffe, S. W., Tagliabracci, V. S., & Guan, K. L. (2015). Differential regulation of mTORC1 by leucine and glutamine. Science, 347, 6218. https://doi.org/10.1126/science.1259472
Khalaf, D., Krüger, M., Wehland, M., Infanger, M., & Grimm, D. (2019). The effects of oral l-arginine and l-citrulline supplementation on blood pressure. Nutrients, 11(7), 1679. https://doi.org/10.3390/nu11071679
Koba, T., Hamada, K., Sakurai, M., Matsumoto, K., Higuchi, T., Zhao, M., & Miyata, H. (2005). Effect Of A Branched-chain Amino Acids Supplementation On Muscle Soreness During Intensive Training Program. Medicine & Science in Sports & Exercise. https://doi.org/10.1249/00005768-200505001-00228
Macuh, M., & Knap, B. (2021). Effects of nitrate supplementation on exercise performance in humans: A narrative review. Nutrients, 13(9), 3183. https://doi.org/10.3390/nu13093183
Mann, G., Mora, S., Madu, G., & Adegoke, O. A. J. (2021). Branched-chain Amino Acids: Catabolism in Skeletal Muscle and Implications for Muscle and Whole-body Metabolism. Frontiers in Physiology, 12(3). https://doi.org/10.3389/fphys.2021.702826
Marcon, M., & Zanella, P. B. (2022). The effect of branched-chain amino acids supplementation in physical exercise: A systematic review of human randomized controlled trials. Science and Sports, 2(3). https://doi.org/10.1016/j.scispo.2021.05.006
Martinho, D. V., Nobari, H., Faria, A., Field, A., Duarte, D., & Sarmento, H. (2022). Oral Branched-Chain Amino Acids Supplementation in Athletes: A Systematic Review. Nutrients, 14(19), 4002. https://doi.org/10.3390/nu14194002
Maughan, R. J., Burke, L. M., Dvorak, J., Larson-Meyer, D. E., Peeling, P., Phillips, S. M., Rawson, E. S., Walsh, N. P., Garthe, I., Geyer, H., Meeusen, R., Van Loon, L. J. C., Shirreffs, S. M., Spriet, L. L., Stuart, M., Vernec, A., Currell, K., Ali, V. M., Budgett, R. G., … Engebretsen, L. (2018). IOC consensus statement: Dietary supplements and the high-performance athlete. British Journal of Sports Medicine, 52(7), 439–455. https://doi.org/10.1136/bjsports-2018-099027
Negro, M., Giardina, S., Marzani, B., & Marzatico, F. (2008). Branched-chain amino acid supplementation does not enhance athletic performance but affects muscle recovery and the immune system. Journal of Sports Medicine and Physical Fitness.
Neinast, M., Murashige, D., & Arany, Z. (2019). Branched Chain Amino Acids. Annual Review of Physiology, 81, 139–164. https://doi.org/10.1146/annurev-physiol-020518-114455
Parry-Billings, M., Blomstrand, E., McAndrew, N., & Newsholme, E. A. (1990). A communicational link between skeletal muscle, brain, and cells of the immune system. International Journal of Sports Medicine, 11(2), S122-128. https://doi.org/10.1055/s-2007-1024863
Rousseau, M., Guénard, F., Garneau, V., Allam-Ndoul, B., Lemieux, S., Pérusse, L., & Vohl, M. C. (2019). Associations between dietary protein sources, plasma BCAA and short-chain acylcarnitine levels in adults. Nutrients, 11(1). https://doi.org/10.3390/nu11010173
Shimomura, Y., & Kitaura, Y. (2018). Physiological and pathological roles of branched-chain amino acids in the regulation of protein and energy metabolism and neurological functions. In Pharmacological Research. https://doi.org/10.1016/j.phrs.2018.05.014
Vahid, I., Abdolali, B., Fatemeh, M., Alireza, N., & Mehdi, S. (2018). The effects of branch-chain amino acids on fatigue in the athletes. Interventional Medicine and Applied Science, 10(4), 233–235. https://doi.org/10.1556/1646.10.2018.10
Vandusseldorp, T. A., Escobar, K. A., Johnson, K. E., Stratton, M. T., Moriarty, T., Cole, N., McCormick, J. J., Kerksick, C. M., Vaughan, R. A., Dokladny, K., Kravitz, L., & Mermier, C. M. (2018). Effect of branched-chain amino acid supplementation on recovery following acute eccentric exercise. Nutrients, 10(10). https://doi.org/10.3390/nu10101389
Vieillevoye, S., Poortmans, J. R., & Carpentier, A. (2020). Effects of essential amino acids supplementation on muscle damage following a heavy-load eccentric training session. Science and Sports, 4(3). https://doi.org/10.1016/j.scispo.2019.06.010
Waskiw-Ford, M., Hannaian, S., Duncan, J., Kato, H., Sawan, S. A., Locke, M., Kumbhare, D., & Moore, D. (2020). Leucine-enriched essential amino acids improve recovery from post-exercise muscle damage independent of increases in integrated myofibrillar protein synthesis in young men. Nutrients, 12(4), 1061. https://doi.org/10.3390/nu12041061
WHO/FAO/UNU Expert Consultation. (2007). WHO Technical Report Series Protein and Amino Acid Requirements in Human Nutrition. WHO Int, 265(935), 1–265. pubmed.ncbi.nlm.nih.gov/18330140/
Zhao, S., Zhou, L., Wang, Q., Cao, J. H., Chen, Y., Wang, W., Zhu, B. Da, Wei, Z. H., Li, R., Li, C. Y., Zhou, G. Y., Tan, Z. J., Zhou, H. P., Li, C. X., Gao, H. K., Qin, X. J., & Lian, K. (2023). Elevated branched-chain amino acid promotes atherosclerosis progression by enhancing mitochondrial-to-nuclear H2O2-disulfide HMGB1 in macrophages. Redox Biology, 62(45), 102696. https://doi.org/10.1016/j.redox.2023.102696
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