HUBUNGAN ANTARA RIWAYAT PENGGUNAAN CEFADROXIL DENGAN KEJADIAN STEVEN-JOHNSON SYNDROME DI RSU Dr.SOEDARSO PONTIANAK PERIODE 2007 - 2010

Abstract

Background: Steven-Johnson syndrome is a hypersensitivity disease was mediated by immune complexes caused by some drugs or infections. The incidence of Stevens-Johnson syndrome induced by drug allergy is increasing in Indonesia. Cefadroxil is a high risk Stevens-Johnson syndrome cause.
Objective: To determine association between history of cefadroxil with the occurrence of Steven-Johnson syndrome at RSU dr.Soedarso Pontianak in period 2007- 2010.
Method: This is an analytic observational with retrospective study. Ninety five samples were participated. Data was processed by chi square test.
Result: Based on the history of the use of cefadroxil, 14 people were diagnosed with Stevens-Johnson Syndrome and 18 people were diagnosed with other forms of Drug Eruption, while based on a history of drug use other types, 26 people were diagnosed with Stevens-Johnson Syndrome and 37 people were diagnosed Drug Eruption. The results show the value of p = 0.817, PR = 1,060, 95% confidence interval = 0.649 to 1.732.
Conclusion: There is no significant association between history of consuming cefadroxil and Steven-Johnson syndrome occurrence.
Keywords: Steven-Johnson syndrome – cefadroxil – RSU dr.Soedarso – 2007-2010