UJI EFEK EKSTRAK ETANOL 70% DAUN BAWANG KUCAI (Allium tuberosum Rottl. ex Spreng) TERHADAP PENURUNAN LOW "“ DENSITY LIPOPROTEIN (LDL) SERUM TIKUS PUTIH JANTAN (Rattus norvegicus) GALUR WISTAR

Abstract

Background : Garlic chives (Allium tuberosum Rottl ex Spreng) contain
organosulphur and secondary metabolite that have an inhibitory effect on
HMG-CoA reductase   and serum Low-Density Lipoprotein lowering property.
Objective: To investigate the effect of Garlic chives extract on serum LDL
and to determine the effective dose to lower   serum LDL in comparison with
pravastatin   Method: This research was an in vivo experimental study.
Twenty five wistar rats were randomized   into 5 groups, positive control group
(pravastatin), negative control group (CMC 1%), dose I (0,0218 g/200gBW),
dose II (0,04365 g/200gBW), Dose III (0,0873 g/200gBW). All rats were given
high cholesterol diet for 14 days to induce higher LDL level. The data was
analyzed with One-way anova and LSD post hoc test. Result : Statistical
analysis showed significant difference between average LDL level from
control groups (negative and positive) and dose I, Dose II, and Dose III
Groups (p<0,05) at day-42. The effective dose was 0,0218 g/200gBW.
Conclusion: Ethanol 70% extract of garlic chives has serum low-density
lipoprotein   lowering effect in rats and dose of   0,0218 g/200gBW showed
equal effectivity with pravastatin
Key Words: Allium tuberosum Rotll ex Spreng, Eth anol 70% extract of garlic chives,
high cholesterol diet, Low-Density Lipoprotein (LDL) level lowering effect
1) Medical School, Faculty of Medicine, Tanjungpura University
Pontianak, West Kalimantan
2) Pharmacy School, Faculty Of medicine, Tanjungpura University
Pontianak, West Kalimantan
3) Departement of   Medical Physiology, Medical School, Faculty of
Medicine, Tanjungpura University Pontianak, West Kalimantan