EFEK HEPATOPROTEKTIF EKSTRAK DAUN KEMUNTING (Rhodomyrtus tomentosa [Aiton] Hassk.) TERHADAP HEPATOTOKSISITAS YANG DIINDUKSI PARASETAMOL

Abstract

Background: Liver has an important role in drug metabolism which
cause liver as the main target of the damage caused by drugs. There are
so many drugs that has been reported to cause hepatotoxicity, one of
them is paracetamol. Hepatotoxicity can be prevented by hepatoprotective
agents. Kemunting (Rhodomyrtus tomentosa [Aiton] Hassk.) leaves has
potency as hepatoprotective agent because it has antioxidant biochemical
content. Objective: The aim of this study was to determine
hepatoprotective effect of Kemunting extract against paracetamol
hepatotoxicity. Methodology: This research used maceration with ethanol
70% as the extraction method. The research was done in 10 days on male
Wistar rats. The rats divided into 6 group; solvent control group (CMC
0,5%), negative control (paracetamol 1000 mg/kg bw on the third, seventh,
and tenth day), positive control (silymarin 200 mg/kg bw), kemunting
leaves extract doses 200, 400, and 800 mg/kg bw. The rats were
sacrificed on the eleventh day to analyze transaminase enzymes (SGOT
and SGPT) and liver microscopic. Data was analyzed using One Way
Anova test. Results: There were elevations of SGOT and SGPT level with
hydrophic degeneration in group given with paracetamol only. Positive
control group (silymarin) and kemunting leaves extract group showed
minimal recoveries but they were not significant in statistical analysis.
Conclusion: The hepatoprotective effect of kemunting extract leaves is
inadequate against paracetamol-induced hepatotoxicity.
Keyword: Rhodomyrtus tomentosa [Aiton] Hassk., paracetamol,
biochemical analysis, liver microscopic
1) Medical Education Program, Faculty of Medicine, University of
Tanjungpura Pontianak, West Borneo.  
2) Pharmacy Program, Faculty of Medicine, University of Tanjungpura
Pontianak, West Borneo.
3) Department of Physiology, Faculty of Medicine, University of
Tanjungpura Pontianak, West Borneo.