UJI EFEK DEKOKTA ANGKAK (BERAS FERMENTASI Monascus purpureus) TERHADAP KADAR TROMBOSIT TIKUS PUTIH JANTAN GALUR WISTAR TROMBOSITOPENIA YANG DIINDUKSI CISPLATIN

Abstract

Background: Thrombocytopenia is the main symptom of dengue
hemorrhagic fever, which is still a major health problem with high morbidity
and mortality rate in West Borneo. Angkak has been used empirically as a
medicine to increase blood cells, particularly to increase thrombocyte
Objective: The objective of this research was to understand the effect of
angkak decoction on thrombocyte in white male Wistar rat with cisplatin
induced thrombocytopenia. Methods: 24 rats were divided into 6
treatment groups. Thrombocytopenia was induced with single dose of 7
mg/Kg BW intravenous. Phytochemical screening was performed to
analyze the content of angkak decoction. Angkak decoction was delivered
orally for 7 days. Thrombocytopenia level wan analyzed using Sysmex
KX-21 hematology analyzer. Result: Phytochemical screening shows that
angkak decoction contains terpenes, flavonoid, phenol, and tannin.
Thrombocyte level in groups which was given angkak decoction oraly
does not have a significant difference with group which was not given
angkak decoction. Conclusion: Angkak decoction oral delivery does not
increase thrombocyte significantly in cisplatin induced thrombocytopenia in
white male Wistar rat compared to negative control group.

Key Words: Thrombocytopenia, decoction, angkak, Monascus purpureus,
Sysmex KX-21 hematology analyzer


Notes:

1) Medical School, Faculty of Medicine, University of Tanjungpura
Pontianak, West Borneo
2) Pharmacy School, Faculty of Medicine, University of Tanjungpura
Pontianak, West Borneo
3) Medical School, Faculty of Medicine, University of Tanjungpura



Pontianak, West Borneo