UJI EFEKTIVITAS ANTIOKSIDAN EKSTRAK ETANOL DAUN PEPAYA (Carica papaya L.) PADA SEDIAAN KRIM TERHADAP DPPH (1,1-diphenyl-2-picrylhydrazil)

Abstract

Abstract: Free radicals are one of the causes of the premature aging. free radicals can be
suppressed by antioxidants. Carica papaya (Carica papaya L.) is one of the plants that potentially
as a natural antioxidant. Ethanol extract of papaya leaves have IC 50 0.58 mg / ml, but not known
in cream. This study aims to determine the IC50 of the ethanol extract of papaya cream using DPPH
(1,1-diphenyl-2-pikrilhidrazil) method. The extraction was done by maceration using ethanol.
Ethanol extract of papaya leaves were obtained is tested phytochemicals, qualitative test with
DPPH and qualitative test of vitamin C with KMnO4. The results of phytochemical screening were
known that contains alkaloids, flavonoids, steroids, and phenolic. The results qualitative DPPH
antioxidant activity and qualitative Vitamin C with KMnO4 showed have antioxidant activity and
vitamin C. Ethanol extract prepared in cream. pH and particle size of cream were good. Creaming
occurs in formulas 4 and the most preferably cream is formula 1. Quantitative test of the ethanol
extract of papaya cream using visible spectrophotometry. The results of spectrophotometric
measurements showed that the ethanol extract of leaves papaya cream has a weak antioxidant
activity with IC50
Keywords: Papaya Leaf, Antioxidants, Ethanol Extracts, DPPH