UJI EFEK PENYEMBUHAN LUKA FASE MINYAK EKSTRAK IKAN TOMAN (Channa micropeltes) PADA TIKUS PUTIH JANTAN WISTAR YANG DIBERI LUKA SAYAT

Abstract

The striped snakehead (Channa striata) has been approved can heal cuts and it is s in the same
family with Giant snakehead (Channa micropeltes). The giant snakehead oil consists of fatty acid-3
and fatty acid-6 and also some other fatty acids which is can help to cure wound healing. This
research aimed to determine the effect of giant snakehead oil which is can help to cure the cuts and
the best dose of giant snakehead oil to accelerate healing process of cuts which is given orally. 15
white male Wistar rats (Rattus novergicus) which are divided into 5 groups, there are group 1 as
negative control), group 2 (0,15 ml/kg the rat weight), group 3 (0,3 ml/kg the rat weight), group 4
(0,57 ml/kg the rat weight and group 5 as comparison. Each group was given cut on their back with a
length of 2 cm, except for the group 5. Then, each group was given the giant snakehead oil for 7 days
and also get controlled of the wound area   on day 0, 1, 3 , 5 and 7. The wound area was measured by
using a programme, that is Macbiophotonic Image J. The data were analyzed by SPSS for Windows
17.0 and using One Way ANOVA and also Post-Hoc Tukey HSD test. There are the significant
differences on day 5 and day 7 (p < 0,05) between all of groups). This result shows that the usage of
giant snakehead oil can help to cure the wound healing. The dose of 0,57 ml/kg the rat weight has the
best effect in healing process of cuts than group 3 and group 2. The percentage is about 93,19%, for
group 3 (0,3 ml/kg the rat weight) is about 87,30% and for the group 2 (0,15 ml/kg the rat weight) is
79,43%
Keywords : Giant snakehead extract, oil based, cuts, fatty acids