POTENSI EKSTRAK METANOL AKAR DAN BATANG KRATOM (Mitragyna speciosa Korth.) SEBAGAI ANTIBAKTERI Propionibacterium acnes ATCC 6919 PENYEBAB JERAWAT

Abstract

Kratom (Mitragyna speciosa) is one type of plant found in tropical regions that have not been optimally utilized as an acne treatment. The kratom plant has potential as an antibacterial agent. This study aims to determine the effect of methanol extract of kratom roots and stems on the growth of Propionibacterium acnes cause acne. The research samples used were roots and stems. The extract method is done by maceration using methanol (PA) solvent. Antibacterial test method used is the Kirby-Bauer method using paper discs. The concentration of methanol extract of kratom roots and stems tested was 5%, 10%, 15%, with a control (+) of 0.003% tetracycline. The results showed that the concentration of methanol extract of kratom root by 5% and kratom stem extract by 10% is the lowest concentration of the best in inhibiting the growth of P. acnes are 5.4 mm and 6.75 mm with medium resistance category. The results of phytocomia screening contained in kratom root extract are alkaloids, phenols, terpenoids, flavonoids, tannins and saponins, while in kratom stem extract are alkaloids, phenols, steroids, terpenoids, flavonoids and tannins.